Discovery of a Novel General Anesthetic Chemotype Using High-throughput Screening
نویسندگان
چکیده
منابع مشابه
Discovery of a novel general anesthetic chemotype using high-throughput screening.
BACKGROUND The development of novel anesthetics has historically been a process of combined serendipity and empiricism, with most recent new anesthetics developed via modification of existing anesthetic structures. METHODS Using a novel high-throughput screen employing the fluorescent anesthetic 1-aminoanthracene and apoferritin as a surrogate for on-pathway anesthetic protein target(s), we s...
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1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand 2Graduate School of Science and Engineering, Yamaguchi University, Yamaguchi 753-8511, Japan 3Department of Veterinary & Biomedical Sciences, College of Agriculture & Biological Sciences, South Dakota State University, Brookings, SD 57006, USA 4Center of Infectious Disease and Signaling Research, Nation...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2015
ISSN: 0003-3022
DOI: 10.1097/aln.0000000000000505